My research vision is to understand how adult stem cells perceive the nutritional states and adjust their fate decisions. I am particularly interested in a previously undefined regenerative program mediated by the fasting and refeeding: a phenomenon referred to as “adaptive multi-organ regeneration”. This phenomenon was first described in the context of a nutrient-sensing insulin/IGF-1 signaling pathway, in hematopoietic system and pancreatic islet. My recent work in intestinal stem cells has revealed a new possibility that endogenous metabolites can instructively regulate adult stem-cell fate. Currently, I am exploring the signaling role of circulating metabolites in the process of adaptive multi-organ regeneration.